Dental Materials
Volume 26, Issue 3 , Pages 232-241 , March 2010

Influence of TEGDMA on the mammalian cell cycle in comparison with chemotherapeutic agents

  • Alexander Eckhardt

      Affiliations

    • Department of Operative Dentistry and Periodontology, University of Regensburg, Franz-Josef-Strauss-Allee 11, D-93042 Regensburg, Germany
    • ,
  • Philipp Müller

      Affiliations

    • Department of Operative Dentistry and Periodontology, University of Regensburg, Franz-Josef-Strauss-Allee 11, D-93042 Regensburg, Germany
    • ,
  • Karl-Anton Hiller

      Affiliations

    • Department of Operative Dentistry and Periodontology, University of Regensburg, Franz-Josef-Strauss-Allee 11, D-93042 Regensburg, Germany
    • ,
  • Stephanie Krifka

      Affiliations

    • Department of Operative Dentistry and Periodontology, University of Regensburg, Franz-Josef-Strauss-Allee 11, D-93042 Regensburg, Germany
    • ,
  • Carola Bolay

      Affiliations

    • Department of Operative Dentistry and Periodontology, University of Regensburg, Franz-Josef-Strauss-Allee 11, D-93042 Regensburg, Germany
    • ,
  • Gianrico Spagnuolo

      Affiliations

    • Department of Oral and Maxillofacial Sciences and Interdisciplinary Research Centre on Biomaterials (CRIB), University of Naples “Federico II”, Italy
    • ,
  • Gottfried Schmalz

      Affiliations

    • Department of Operative Dentistry and Periodontology, University of Regensburg, Franz-Josef-Strauss-Allee 11, D-93042 Regensburg, Germany
    • ,
  • Helmut Schweikl

      Affiliations

    • Department of Operative Dentistry and Periodontology, University of Regensburg, Franz-Josef-Strauss-Allee 11, D-93042 Regensburg, Germany
    • Corresponding Author InformationCorresponding author. Tel.: +49 941 944 6142; fax: +49 941 944 6025.

Received 3 July 2009 ,Revised 9 October 2009 ,Accepted 16 October 2009.

References 

  1. Nyberg KA, Michelson RJ, Putnam CW, Weinert TA. Toward maintaining the genome: DNA damage and replication checkpoints. Annu Rev Genet. 2002;36:617–656
  2. Attardi LD, de Vries A, Jacks T. Activation of the p53-dependent G1 checkpoint response in mouse embryo fibroblasts depends on the specific DNA damage inducer. Oncogene. 2004;23:973–980
  3. Wold LE, Aberle NS, Ren J. Doxorubicin induces cardiomyocyte dysfunction via a p38 MAP kinase-dependent oxidative stress mechanism. Cancer Detect Prev. 2005;29:294–299
  4. Franchittof A, Pichierri P, Mosesso P, Palitti F. Caffeine effect on the mitotic delay induced by G2 treatment with UVC or mitomycin C. Mutagenesis. 1998;13:499–505
  5. Schweikl H, Spagnuolo G, Schmalz G. Genetic and cellular toxicology of dental resin monomers. J Dent Res. 2006;85:870–877
  6. Schweikl H, Altmannsberger I, Hanser N, Hiller KA, Bolay C, Brockhoff G, et al. The effect of triethylene glycol dimethacrylate on the cell cycle of mammalian cells. Biomaterials. 2005;26:4111–4118
  7. Chang HH, Guo MK, Kasten FH, Chang MC, Huang GF, Wang YL, et al. Stimulation of glutathione depletion, ROS production and cell cycle arrest of dental pulp cells and gingival epithelial cells by HEMA. Biomaterials. 2005;26:745–753
  8. Eckhardt A, Gerstmayr N, Hiller KA, Bolay C, Waha C, Spagnuolo G, et al. TEGDMA-induced oxidative DNA damage and activation of ATM and MAP kinases. Biomaterials. 2009;30:2006–2014
  9. Schweikl H, Schmalz G. Triethylene glycol dimethacrylate induces large deletions in the hprt gene of V79 cells. Mutat Res. 1999;438:71–78
  10. Mantellini MG, Botero TM, Yaman P, Dennison JB, Hanks CT, Nor JE. Adhesive resin induces apoptosis and cell-cycle arrest of pulp cells. J Dent Res. 2003;82:592–596
  11. Radcliff G, Jaroszeski MJ. Basics of flow cytometry. Methods Mol Biol. 1998;91:1–24
  12. Gilles RJ, Didier N, Denton M. Determination of cell number in monolayer cultures. Anal Biochem. 1986;159:109–113
  13. Reichl FX, Seiss M, Marquardt W, Kleinsasser N, Schweikl H, Kehe K, et al. Toxicity potentiation by H2O2 with components of dental restorative materials on human oral cells. Arch Toxicol. 2008;82:21–28
  14. Schweikl H, Hartmann A, Hiller KA, Spagnuolo G, Bolay C, Brockhoff G, et al. Inhibition of TEGDMA and HEMA-induced genotoxicity and cell cycle arrest by N-acetylcysteine. Dent Mater. 2007;23:688–695
  15. He Z, Ma WY, Hashimoto T, Bode AM, Yang CS, Dong Z. Induction of apoptosis by caffeine is mediated by the p53, Bax, and caspase 3 pathways. Cancer Res. 2003;63:4396–4401
  16. Takahashi N, Murayama T, Oda M, Miyakoshi M. Cell growth inhibition and DNA incorporation of mitomycin C in cell culture. Ophthalmic Res. 1998;30:120–125
  17. Kroemer G, Petit P, Zamzami N, Vayssiere JL, Mignotte B. The biochemistry of programmed cell death. FASEB J. 1995;9:1277–1287
  18. Schweikl H, Schmalz G, Spruss T. The induction of micronuclei in vitro by unpolymerized resin monomers. J Dent Res. 2001;80:1615–1620
  19. Kleinsasser NH, Schmid K, Sassen AW, Harreus UA, Staudenmaier R, Folwaczny M, et al. Cytotoxic and genotoxic effects of resin monomers in human salivary gland tissue and lymphocytes as assessed by the single cell microgel electrophoresis (Comet) assay. Biomaterials. 2006;27:1762–1770
  20. Reliene R, Fischer E, Schiestl RH. Effect of N-acetyl cysteine on oxidative DNA damage and the frequency of DNA deletions in Atm-deficient mice. Cancer Res. 2004;64:5148–5153
  21. Fornari FA, Randolph JK, Yalowich JC, Ritke MK, Gewirtz DA. Interference by doxorubicin with DNA unwinding in MCF-7 breast tumor cells. Mol Pharmacol. 1994;45:649–656
  22. Wang S, Konorev EA, Kotamraju S, Joseph J, Kalivendi S, Kalyanaraman B. Doxorubicin induces apoptosis in normal and tumor cells via distinctly different mechanisms: intermediacy of H2O2- and p53-dependent pathways. J Biol Chem. 2004;279:25535–25543
  23. Ho CC, Siu WY, Chow JPH, Lau A, Arooz T, Tong HY, et al. The relative contribution of CHK1 and CHK2 to adriamycin-induced checkpoint. Exp Cell Res. 2005;304:1–15
  24. Bae JB, Mukhopadhyay SS, Liu L, Zhang N, Tan J, Akhter S, et al. Snm1B//Apollo mediates replication fork collapse and S phase checkpoint activation in response to DNA interstrand cross-links. Oncogene. 2008;27:5045–5056
  25. Islaih M, Halstead BW, Kadura IA, Li B, Reid-Hubbard JL, Flick L, et al. Relationships between genomic, cell cycle, and mutagenic responses of TK6 cells exposed to DNA damaging chemicals. Mutat Res. 2005;578:100–116
  26. Hassan F, Islam S, Mu MM, Ito H, Koide N, Mori I, et al. Lipopolysaccharide prevents doxorubicin-induced apoptosis in RAW 264.7 macrophage cells by inhibiting p53 activation. Mol Cancer Res. 2005;3:373–379
  27. Samuelsen JT, Dahl JE, Karlsson S, Morisbak E, Becher R. Apoptosis induced by the monomers HEMA and TEGDMA involves formation of ROS and differential activation of the MAP-kinases p38, JNK and ERK. Dent Mater. 2007;23:34–39
  28. Oliveira-Brett AM, Paquim AMC, Diculescu VC, Piedade JAP. Electrochemistry of nanoscale DNA surface films on carbon. Med Eng Phys. 2006;28:963–970
  29. Friesen C, Uhl M, Pannicke U, Schwarz K, Miltner E, Debatin KM. DNA–ligase IV and DNA–protein kinase play a critical role in deficient caspases activation in apoptosis-resistant cancer cells by using doxorubicin. Mol Biol Cell. 2008;19:3283–3289
  30. Sabisz M, Skladanowski A. Modulation of cellular response to anticancer treatment by caffeine: inhibition of cell cycle checkpoints, DNA repair and more. Curr Pharm Biotechnol. 2008;9:325–336
  31. Kaufmann WK, Heffernan TP, Beaulieu LM, Doherty S, Frank AR, Zhou Y, et al. Caffeine and human DNA metabolism: the magic and the mystery. Mutat Res. 2003;532:85–102
  32. Ito K, Nakazato T, Miyakawa Y, Yamato K, Ikeda Y, Kizaki M. Caffeine induces G2/M arrest and apoptosis via a novel p53-dependent pathway in NB4 promyelocytic leukemia cells. J Cell Physiol. 2003;196:276–283
  33. Hashimoto T, He Z, Ma WY, Schmid PC, Bode AM, Yang CS, et al. Caffeine inhibits cell proliferation by G0/G1 phase arrest in JB6 cells. Cancer Res. 2004;64:3344–3349
  34. Samuelsen JT, Holme JA, Becher R, Karlsson S, Morisbak E, Dahl JE. HEMA reduces cell proliferation and induces apoptosis in vitro. Dent Mater. 2008;24:134–140
  35. Kastan MB, Onyekwere O, Sidransky D, Vogelstein B, Craig RW. Participation of p53 protein in the cellular response to DNA damage. Cancer Res. 1991;51:6304–6311
  36. Sarkaria JN, Busby EC, Tibbetts RS, Roos P, Taya Y, Karnitz LM, et al. Inhibition of ATM and ATR kinase activities by the radiosensitizing agent, caffeine. Cancer Res. 1999;59:4375–4382
  37. Alvira D, Yeste-Velasco M, Folch J, Casadesus G, Smith MA, Pallas M, et al. Neuroprotective effects of caffeine against complex I inhibition-induced apoptosis are mediated by inhibition of the Atm/p53/E2F-1 path in cerebellar granule neurons. J Neurosci Res. 2007;85:3079–3088
  38. Ishii Y, Bender MA. Caffeine inhibition of prereplication repair of mitomycin C-induced DNA damage in human peripheral lymphocytes. Mutat Res. 1978;51:419–425
  39. Kawata T, Ito H, Saito M, Uno T, Okayasu R, Liu C, et al. Caffeine sensitizes nondividing human fibroblasts to X-rays by inducing a high frequency of misrepair. Radiat Res. 2005;164:509–513

PII: S0109-5641(09)00333-9

doi: 10.1016/j.dental.2009.10.005

Dental Materials
Volume 26, Issue 3 , Pages 232-241 , March 2010

Article Tools

* Image Usage & Resolution