Dental Materials
Volume 25, Issue 7 , Pages 863-867, July 2009

Biocompatibility of resin composites subcutaneously implanted in rats with experimentally induced arthritis

  • M. Anagnostou

      Affiliations

    • Department of Pharmacology, Medical School, University of Athens, 75 Mikras Asias St., Goudi, Athens 11527, Greece
    • Corresponding Author InformationCorresponding author. Fax: +30 210 7462554.
    • ,
  • E. Chatzigianni

      Affiliations

    • Department of Pathology, General District Accident Hospital “KAT”, Kifissia, Athens, Greece
    • ,
  • S. Doucoudakis

      Affiliations

    • Department of Operative Dentistry, Dental School, University of Athens, Greece
    • ,
  • A. Potamianou

      Affiliations

    • Department of Microbiology, Asklipio General Hospital of Voula, Athens, Greece
    • ,
  • C. Tesseromatis

      Affiliations

    • Department of Pharmacology, Medical School, University of Athens, 75 Mikras Asias St., Goudi, Athens 11527, Greece

Received 8 August 2008; received in revised form 20 August 2008; accepted 8 September 2008.

Abstract 

Objective

To evaluate the biocompatibility of resin composite specimens with different curing efficiency, subcutaneously implanted in rats with experimentally induced arthritis.

Methods

The amount of remaining CC bonds (%RDB) of hybrid resin composite specimens photopolymerized for 10s and 40s exposure time (n=3) was measured by micro-attenuated total reflectance Fourier transform infrared spectroscopy. Male Wistar rats (n=36) were classified in two groups (n=18) of healthy animals and of animals with experimentally induced arthritis. Resin composite specimens irradiated for 10s and 40s and calcium hydroxide control specimens were implanted subcutaneously in each animals’ dorsum. Following 2-, 4- and 9-week periods the animals were sacrificed. The development of arthritis was defined by biochemical analysis and the changes in the relative weight of animals’ organs (spleen, thymus, adrenals). Tissue reactions were examined histologically.

Results

%RDB per site and exposure time showed statistically significant differences. Lowest %RDB values were recorded on 40s exposed specimens. Biochemical indices and relative organ weights demonstrated statistically significant differences between healthy animals and animals with arthritis. The health status of the animals and the materials used did not influence tissue response. First and second periods of sacrifice showed reduced propensity of connective tissue development in comparison to the third period. The same applied for the second period regarding the presence of giant cells.

Significance

The materials tested and the animals’ health status did not result in altered tissue response compared to control group. The period of sacrifice was associated with different tissue responses.

Keywords: Biocompatibility, Implantation tests, Resin composites, Rat adjuvant arthritis

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PII: S0109-5641(09)00010-4

doi:10.1016/j.dental.2008.09.012

Dental Materials
Volume 25, Issue 7 , Pages 863-867, July 2009

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