Dental Materials
Volume 22, Issue 4 , Pages 353-358, April 2006

The effects of BIS-GMA and TEG-DMA on female mouse fertility

  • Homa Darmani

      Affiliations

    • Department of Applied Biology, Faculty of Science, Jordan University of Science and Technology, P.O. Box 3030, Irbid 22110, Jordan
    • Corresponding Author InformationCorresponding author. Tel.: +962 79 5978834; fax: +962 2 7278962.
    • ,
  • Ahmad S. Al-Hiyasat

      Affiliations

    • Department of Restorative Dentistry, Faculty of Dentistry, Jordan University of Science and Technology, P.O. Box 3030, Irbid 22110, Jordan

Received 25 November 2004; received in revised form 7 March 2005; accepted 24 April 2005.

Summary 

Objectives

The current study evaluated the effect of bisphenol A glycerolate dimethacrylate (BIS-GMA) and triethyleneglycol dimethacrylate (TEG-DMA) on female mouse fertility.

Methods

Adult female mice were exposed to BIS-GMA or TEG-DMA (0, 25 and 100μg/kg) intragastrically daily for 28 d and then mated with sexually mature untreated male mice and after mating their fertility was assessed.

Results

In females exposed to BIS-GMA at both doses significant increases in the total number of resorptions out of the total number of implantations were observed, with a significant increase in the number of animals with resorptions at the higher dose. Significant reductions in body weights and significant increases in ovary weights were also observed. Exposure to TEG-DMA at a dose of 100μg/kg resulted in significant reductions in pregnancy rates and a significant increase in the total number of embryonal resorptions. Significant reductions in body and uterine weights were also observed in females exposed to TEG-DMA.

Significance

The results suggest that both BIS-GMA and TEG-DMA have reproductive toxic effects in female mice.

Keywords: Reproductive toxicity, Resin composite, Pregnancy, Embryonal resorptions

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PII: S0109-5641(05)00184-3

doi:10.1016/j.dental.2005.04.029

Dental Materials
Volume 22, Issue 4 , Pages 353-358, April 2006

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