Dental Materials
Volume 22, Issue 4 , Pages 338-345 , April 2006

In vitro cytotoxicity of a remineralizing resin-based calcium phosphate cement

  • Edward J. Boland

      Affiliations

    • Department of Periodontics, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    • ,
  • Mary MacDougall

      Affiliations

    • Department of Pediatric Dentistry, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    • ,
  • David L. Carnes

      Affiliations

    • Department of Periodontics, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    • ,
  • Sabine H. Dickens

      Affiliations

    • Paffenbarger Research Center, American Dental Association Foundation, National Institute of Standards and Technology, 100 Bureau Dr. Stop 8546, Gaithersburg, MD 20899-8546, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1 301 975 6802; fax: +1 301 963 9143.

Received 6 January 2005 ,Accepted 12 May 2005.

References 

  1. Jarcho M. Calcium phosphate ceramics as hard tissue prosthetics. Clin Orthop. 1981;259–278
  2. Yokoyama A, Matsuno H, Yamamoto S, Kawasaki T, Kohgo T, Uo M, et al. Tissue response to a newly developed calcium phosphate cement containing succinic acid and carboxymethyl-chitin. J Biomed Mater Res. 2003;64A:491–501
  3. Dickens S, Flaim G, Takagi S. Mechanical properties and biochemical activity of remineralizing resin-based Ca–PO4 cements. Dent Mater. 2003;19:558–566
  4. Brown W, Chow LC. In:  Westerville O,  Brown P editor. A new calcium phosphate, water-setting cement: cements research progress 1986. American Ceramic Society; 1987;p. 352–379
  5. Jorge J, Giampaolo E, Machado A, Vergani C. Cytotoxicity of denture base acrylic resins: a literature review. J Prosthet Dent. 2003;90:190–193
  6. Mohsen N, Craig R, Hanks C. Cytotoxicity of urethane dimethacrylate composites before and after aging and leaching. J Biomed Mater Res. 1998;39:252–260
  7. Wataha JC. Principles of biocompatibility for dental practitioners. J Prosthet Dent. 2001;86:203–209
  8. Wataha JC, Hanks CT, Strawn SE, Fat JC. Cytotoxicity of components of resins and other dental restorative materials. J Oral Rehabil. 1994;21:453–462
  9. Hanks CT, Wataha JC, Sun Z. In vitro models of biocompatibility: a review. Dent Mater. 1996;12:186–193
  10. Schmalz G. Concepts in biocompatibility testing of dental restorative materials. Clin Oral Investig. 1997;1:154–162
  11. Dickens-Venz SH, Takagi S, Chow LC, Bowen RL, Johnston AD, Dickens B. Physical and chemical properties of resin-reinforced calcium phosphate cements. Dent Mater. 1994;10:100–106
  12. MacDougall M, Selden JK, Nydegger JR, Carnes DL. Immortalized mouse odontoblast cell line MO6-G3 application for in vitro biocompatibility testing. Am J Dent. 1998;11:S11–S16
  13. Messer RL, Lockwood PE, Wataha JC, Lewis JB, Norris S, Bouillaguet S. In vitro cytotoxicity of traditional versus contemporary dental ceramics. J Prosthet Dent. 2003;90:452–458
  14. MacDougall M, Thiemann F, Ta H, Hsu P, Chen LS, Snead ML. Temperature sensitive simian virus 40 large T antigen immortalization of murine odontoblast cell cultures: establishment of clonal odontoblast cell line. Connect Tissue Res. 1995;33:97–103
  15. Yoshii E. Cytotoxic effects of acrylates and methacrylates: relationships of monomer structures and cytotoxicity. J Biomed Mater Res. 1997;37:517–524
  16. Schmalz G. Use of cell cultures for toxicity testing of dental materials—advantages and limitations. J Dent. 1994;2(Suppl. 2):S6–S11
  17. Lawrence WH, Bass GE, Purcell WP, Autian J. Use of mathematical models in the study of structure-toxicity relationships of dental compounds. I. Esters of acrylic and methacrylic acids. J Dent Res. 1972;51:526–535
  18. McCarthy TJ, Witz G. Structure–activity relationships in the hydrolysis of acrylate and methacrylate esters by carboxylesterase in vitro. Toxicology. 1997;116:153–158
  19. Fujisawa S, Imai Y, Kojima K, Masuhara E. Studies on hemolytic activity of bisphenol A diglycidyl methacrylate (BIS-GMA). J Dent Res. 1978;57:98–102
  20. Wataha JC, Rueggeberg FA, Lapp CA, Lewis JB, Lockwood PE, Ergle JW, et al. In vitro cytotoxicity of resin-containing restorative materials after aging in artificial saliva. Clin Oral Investig. 1999;3:144–149
  21. Szep S, Kunkel A, Ronge K, Heidemann D. Cytotoxicity of modern dentin adhesives–in vitro testing on gingival fibroblasts. J Biomed Mater Res. 2002;63:53–60
  22. Ferracane JL, Condon JR. Rate of elution of leachable components from composite. Dent Mater. 1990;6:282–287
  23. Kim S, Liu M, Markowitz K, Bilotto G, Dorscher-Kim J. Comparison of pulpal blood flow in dog canine teeth determined by the laser Doppler and the 133xenon washout methods. Arch Oral Biol. 1990;35:411–413
  24. Matthews B, Andrew D. Microvascular architecture and exchange in teeth. Microcirculation. 1995;2:305–313
  25. Boland EJ, Carnes DL, MacDougall MJ, Satsangi N, Norling BK, Rawls HR, et al. Cell survival and cytokine expression by dental cells treated with a liquid crystal resin monomer. J Dent Res. 2001;80(Special Issue):A151;Abstract No. 928
  26. Arenholt-Bindslev D, Horsted-Bindslev P. A simple model for evaluating relative toxicity of root filling materials in cultures of human oral fibroblasts. Endod Dent Traumatol. 1989;5:219–226
  27. Schweikl H, Schmalz G. Toxicity parameters for cytotoxicity testing of dental materials in two different mammalian cell lines. Eur J Oral Sci. 1996;104:292–299
  28. Feigal RJ, Yesilsoy C, Messer HH, Nelson J. Differential sensitivity of normal human pulp and transformed mouse fibroblasts to cytotoxic challenge. Arch Oral Biol. 1985;30:609–613
  29. Dickens SH, Schumacher GE, Flaim GM, Schafer DR. Pulp capping with a resin-based Ca–PO4 cement. J Dent Res. 2001;80(Special Issue):740;Abstract No. 1710

PII: S0109-5641(05)00182-X

doi: 10.1016/j.dental.2005.05.004

Dental Materials
Volume 22, Issue 4 , Pages 338-345 , April 2006

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